Clinical Research & Reference

Restorative Therapies for Critical Care

Research is continuously being conducted demonstrating the many benefits of early mobilization in the ICU and critical care environments. The results have led to many articles being published in peer-reviewed scientific journals.

Sample Publications

  • ICU early physical rehabilitation programs: financial modeling of cost savings.
    Lord RK, Mayhew CR, Korupolu R, Mantheiy EC, Friedman MA, Palmer JB, Needham DM. Crit Care Med. 2013 Mar;41(3):717-24.
  • Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis.
    Hermans G, Van Mechelen H, Clerckx B, Vanhullebusch T, Mesotten D, Wilmer A, Casaer MP, Meersseman P, Debaveye Y, Van Cromphaut S, Wouters PJ, Gosselink R, Van den Berghe G. Am J Respir Crit Care Med. 2014 Aug 15;190(4):410-20.
  • Mobile, awake and critically ill.
    Herridge MS. CMAJ. 2008 Mar 11;178(6):725-6.
  • Functional electrical stimulation with cycling in the critically ill: a pilot case-matched control study.
    Parry SM, Berney S, Warrillow S, El-Ansary D, Bryant AL, Hart N, Puthucheary Z, Koopman R, Denehy L. J Crit Care. 2014 Aug;29(4):695.e1-7.
  • Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial.
    Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP. Lancet. 2009 May 30;373(9678):1874-82. 
  • Early physical medicine and rehabilitation for patients with acute respiratory failure: quality improvement project.
    Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E. Arch Phys Med Rehabil. 2010 Apr;91(4):536-42. 
  • Feasibility and Effectiveness of a Delirium Prevention Bundle in Critically Ill Patients.
    Smith CD, Grami P. Am J Crit Care. 2016 Dec;26(1):19-27.
  • Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients.
    Kho ME, Molloy AJ, Clarke FJ, Reid JC, Herridge MS, Karachi T, Rochwerg B, Fox-Robichaud AE, Seely AJ, Mathur S, Lo V, Burns KE, Ball IM, Pellizzari JR, Tarride JE, Rudkowski JC, Koo K, Heels-Ansdell D, Cook DJ. BMJ Open Respir Res. 2019 Feb 18;6(1):e000383
  • TryCYCLE: A Prospective Study of the Safety and Feasibility of Early In-Bed Cycling in Mechanically Ventilated Patients.
    Kho ME, Molloy AJ, Clarke FJ, Ajami D, McCaughan M, Obrovac K, Murphy C, Camposilvan L, Herridge MS, Koo KK, Rudkowski J, Seely AJ, Zanni JM, Mourtzakis M, Piraino T, Cook DJ; Canadian Critical Care Trials Group. PLoS One. 2016 Dec 28;11(12):e0167561.
  • Critical Care Cycling Study (CYCLIST) trial protocol: a randomized controlled trial of usual care plus additional in-bed cycling sessions versus usual care in the critically ill.
    Nickels MR, Aitken LM, Walsham J, Barnett AG, McPhail SM. BMJ Open. 2017 Oct 22;7(10):e017393.
  • Sedation and Mobilization During Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Failure: An International Survey.
    Marhong JD, DeBacker J, Viau-Lapointe J, Munshi L, Del Sorbo L, Burry L, Fan E, Mehta S. Crit Care Med. 2017 Nov;45(11):1893-1899.
  • Early Exercise in Critically Ill Youth and Children, a Preliminary Evaluation: The wEECYCLE Pilot Trial.
    Choong K, Awladthani S, Khawaji A, Clark H, Borhan A, Cheng J, Laskey S, Neu C, Sarti A, Thabane L, Timmons BW, Zheng K, Al-Harbi S; Canadian Critical Care Trials Group. Pediatr Crit Care Med. 2017 Nov;18(11):e546-e554.